What Is EBOO Therapy? A Guide for Palm Beach and Jupiter Residents

May 29, 2026; By Benjamin Kosubevsky

If you live in Palm Beach, Jupiter, or the surrounding North County communities, you may have heard the term EBOO mentioned in conversations about integrative medicine and wellness. But what is it, exactly, and why is it generating so much interest among patients seeking alternatives to conventional approaches?

EBOO: The Basics

EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. It is a form of ozone therapy in which a patient’s blood is drawn, passed through a specialized filtration and ozonation system outside the body, and then returned. The process exposes the blood to a precisely calibrated mixture of medical-grade ozone and oxygen. Ozone therapy as a broader category has been reviewed in the peer-reviewed literature, with researchers describing its potential mechanisms of action including modulation of oxidative stress and immune signaling (Bocci, Archives of Medical Research, 2006).

What distinguishes EBOO from other forms of ozone therapy—such as major autohemotherapy (MAH), in which a smaller volume of blood is treated in a syringe—is the volume of blood processed and the use of an external filtration circuit. EBOO systems typically process a larger portion of the patient’s blood volume in a single session.

How Does Ozone Interact with the Body?

When ozone contacts blood, it rapidly reacts with organic compounds to produce a cascade of signaling molecules, including lipid oxidation products that may activate the body’s antioxidant defense pathways. A review published in Medical Gas Research described these mechanisms as a “hormetic” response—a mild, controlled oxidative stimulus that may upregulate the body’s own protective systems (Sagai & Bocci, Med Gas Res, 2011).

An additional clinical review noted that ozone therapy has been studied in a range of clinical contexts, though the authors emphasized that the quality of evidence varies and that larger, controlled trials are still needed to establish definitive clinical recommendations (Elvis & Ekta, Journal of Natural Science, Biology and Medicine, 2011).

What Happens During an EBOO Session?

At The Longevity Center FL in West Palm Beach, EBOO is administered under physician supervision. A typical session involves drawing blood through an intravenous line, passing it through the ozone-oxygen exposure and filtration system, and returning the treated blood to the patient. Sessions generally last 45 minutes to one hour. Patients are monitored throughout the procedure.

Residents of Palm Beach, Jupiter, North Palm Beach, and the surrounding communities can access this service at our clinic located at 580 Village Blvd, Suite 210, just minutes from I-95 and the Turnpike.

Who Explores EBOO?

Patients who express interest in EBOO therapy at our clinic typically fall into a few categories: those investigating immune wellness support, those exploring complementary approaches to managing oxidative stress and inflammation, and those who have researched ozone therapy independently and want physician-supervised access to the most advanced delivery method available.

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References

1. Bocci V. Scientific and Medical Aspects of Ozone Therapy: State of the Art. Archives of Medical Research. 2006;37(4):425-435.[Full Text]
2. Sagai M, Bocci V. Mechanisms of Action Involved in Ozone Therapy: Is Healing Induced via a Mild Oxidative Stress? Medical Gas Research. 2011;1(1):29. [Full Text]
3. Elvis AM, Ekta JS. Ozone Therapy: A Clinical Review. Journal of Natural Science, Biology and Medicine. 2011;2(1):66-70. [Full Text]